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		<title>Ultrafast and specific miRNA quantification via single-molecule fluorescence quenching kinetics</title>
		<link>https://smb.snu.ac.kr/2026/02/14/ultrafast-and-specific-mirna-quantification-via-single-molecule-fluorescence-quenching-kinetics/</link>
		
		<dc:creator><![CDATA[wolley dapeton]]></dc:creator>
		<pubDate>Fri, 13 Feb 2026 15:00:00 +0000</pubDate>
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		<guid isPermaLink="false">https://smb.snu.ac.kr/2026/02/14/ultrafast-and-specific-mirna-quantification-via-single-molecule-fluorescence-quenching-kinetics/</guid>

					<description><![CDATA[Rapid and precise detection of multiple nucleic acid biomarkers is crucial for the development of clinically practical molecular diagnostics. The analytic specificity of biomarker detection can be greatly enhanced by utilizing the information of single-molecule probe binding kinetics. However, existing single-molecule fluorescence methods require up to 10 minutes per biomarker due to the slow binding rates...]]></description>
		
		
		
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		<title>Analytical techniques for nucleic acid and protein detection with single-molecule sensitivity</title>
		<link>https://smb.snu.ac.kr/2025/05/01/analytical-techniques-for-nucleic-acid-and-protein-detection-with-single-molecule-sensitivity/</link>
		
		<dc:creator><![CDATA[wolley dapeton]]></dc:creator>
		<pubDate>Wed, 30 Apr 2025 15:00:00 +0000</pubDate>
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		<guid isPermaLink="false">https://smb.snu.ac.kr/2025/05/01/analytical-techniques-for-nucleic-acid-and-protein-detection-with-single-molecule-sensitivity/</guid>

					<description><![CDATA[Nucleic acids and proteins serve as crucial biomarkers used in the diagnosis, prognosis and therapy monitoring across various diseases. Traditionally, these biomarkers are identified at an ensemble level following the amplification of target or signaling molecules. However, these methods have limitations in addressing contemporary challenges in molecular diagnostics, such as low sensitivity, specificity, throughput and...]]></description>
		
		
		
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		<title>Kinesin-like protein KIF18A is required for faithful coordination of chromosome congression with cytokinesis</title>
		<link>https://smb.snu.ac.kr/2025/02/15/kinesin-like-protein-kif18a-is-required-for-faithful-coordination-of-chromosome-congression-with-cytokinesis/</link>
		
		<dc:creator><![CDATA[wolley dapeton]]></dc:creator>
		<pubDate>Fri, 14 Feb 2025 15:00:00 +0000</pubDate>
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					<description><![CDATA[The maintenance of genetic integrity in proliferating cells requires the coordinated regulation of DNA replication, chromosome segregation, and cytokinetic abscission. Chromosome-microtubule interactions regulate mitosis, while interactions between the actin cytoskeleton and Myosin IIA dictate cytokinetic abscission. This process, crucial for the equal distribution of the duplicated genome into two daughter cells, occurs perpendicular to the...]]></description>
		
		
		
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		<title>Single-mode termination of phage transcriptions, disclosing bacterial adaptation for facilitated reinitiations</title>
		<link>https://smb.snu.ac.kr/2024/08/27/single-mode-termination-of-phage-transcriptions-disclosing-bacterial-adaptation-for-facilitated-reinitiations/</link>
		
		<dc:creator><![CDATA[wolley dapeton]]></dc:creator>
		<pubDate>Mon, 26 Aug 2024 15:00:00 +0000</pubDate>
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					<description><![CDATA[Bacterial and bacteriophage RNA polymerases (RNAPs) have divergently evolved and share the RNA hairpin-dependent intrinsic termination of transcription. Here, we examined phage T7, T3 and SP6 RNAP terminations utilizing the single-molecule fluorescence assays we had developed for bacterial terminations. We discovered the phage termination mode or outcome is virtually single with decomposing termination. Therein, RNAP...]]></description>
		
		
		
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		<title>Compatibility of termination mechanisms in bacterial transcription with inference on eukaryotic models</title>
		<link>https://smb.snu.ac.kr/2024/03/27/compatibility-of-termination-mechanisms-in-bacterial-transcription-with-inference-on-eukaryotic-models/</link>
		
		<dc:creator><![CDATA[wolley dapeton]]></dc:creator>
		<pubDate>Tue, 26 Mar 2024 15:00:00 +0000</pubDate>
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					<description><![CDATA[Transcription termination has evolved to proceed through diverse mechanisms. For several classes of terminators, multiple models have been debatably proposed. Recent single-molecule studies on bacterial terminators have resolved several long-standing controversies. First, termination mode or outcome is twofold rather than single. RNA is released alone before DNA or together with DNA from RNA polymerase (RNAP),...]]></description>
		
		
		
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